SNIFFER – Plateforme nano-intégrée à ondes acoustiques de surface pour les maladies intestinales inflammatoires : système prédictif de la flore bactérienne pour la détection d’HElicobacter pylori BiomarkeRs
The "SNIFFER" project aims to develop a smart and autonomous device capable of accurately detecting and identifying biomarkers such as carbon dioxide (CO₂) and ammonia (NH₃), which are key indicators of the health status of patients suffering from intestinal infections, notably those caused by the presence of a specific bacterium. This is due to the activity of urease, an enzyme produced by H. pylori that breaks down urea into ammonia and carbon dioxide. To date, no solution offers rapid, real-time, quantified, and reliable detection of these biomarkers in a clinical environment. Our objective is therefore to design an innovative multi-sensor platform capable of simultaneously discriminating these two biological markers within the complex gas mixture exhaled in patients' breath. The target molecules can be measured accurately and reproducibly, capitalizing on different integration methods of organic materials such as semiconductor polymers (poly(3-hexylthiophene) P3HT, PolyeraTM N2200) [127] or conductive polymers (PEDOT:PSS, Poly(aniline)), coupled with bio-inspired molecules acting as Lewis acids.
- October 2023 to October 2026
- Lille
