We work to propose advanced computational methodologies to better understand the influence of aging and degeneration on the mechanical response of different spinal discs, providing predictive tools for evaluating their behavior under varying loading conditions.
The project relies on an integrated experimentation/modeling/simulation approach :
- Experimental characterization of intervertebral disc tissues under different multi-axial loads and environmental conditions
- Multi-scale and multiphysics modeling linking microstructure to mechanical response, including chemo-mechanical-biological interactions
- Numerical simulation using finite element codes to reproduce disc behavior at multiple scales (microstructural, regional, whole disc) and in configurations inspired by MRI data
- Multi-scale model validation against experimental data to ensure realistic representation of mechanical behavior
- Optimization of tools to enable the creation of personalized models and predict degenerative evolution under various loading and degradation scenarios
This project will enhance understanding of aging and degeneration mechanisms in intervertebral discs and provide a solid basis for developing a preventive clinical tool.
It is conducted in collaboration with ICAM, the LGCgE, and Hôpital Ramsay Santé - Lille, and benefits from support and co-funding by the Hauts-de-France region.
Campus Lille
